A comprehensive analytical review applying a six-layer investigative framework has found no credible evidence that Respiratory Syncytial Virus (RSV) originated in or escaped from a laboratory
Thanks Drs. Malone. Outstanding report and conclusions and proof-of AI Value.
Personal to me because my infant son spent days in Stanford Hospital with Dx: Bronchiolitis. I’ve always assumed RSV and that it was Endemic.
Some parent guilt because his mother and I both worked on the Cell Biology corridor separated only by a single door from the Small Animal Research module. Comtainment standard of the day was cotton lab coats, automatic door, and No Odor Control.
Animal Research was limited to inflamation and assay of antiinflamatory drug candidates but there was an annual All Hands/Labs assay “month” in our wing to process beef organs for steriod residual from our (Syntex’s) large scale field trials. ( Family dogs feasted on beef liver and kidney).
SRI was very close but it was Syntex USA Inc. founded by Carl Djerassi with others including Dr Abe White, my personal mentor. Syntex was originally founded in Mexico to complete the synthesis of Progesterone from a precursor extracted from the mexican yam. It became the bulk active ingredient in the first birth control pill. That story is told in Djerassi’s book “The Pill, Pygmy Chimps and Degas’ Horse”.
Dr White is described in the book as “Flash”, an emmigrant post doc found working in a Harvard lab attempting steroid total synthesis. He was also main author of “Principles of Biochemistry” (White, Handler and Smith). You might have used it in Med School?
I brought large scale chromatography to Dr White’s Department of Cell Biology to purify enough of a peptide, found in pooled human plasma, for characterization and trial as a Thymocyte “stimulant” that we called “Thymosyn”.
Successful syntex products included Synalar and Aleve.🤓
So...let's go one step further on RSV. Patients with RSV should be tested for blood value of Vitamin D which is a major component of a whole and vibrant immune system which is the number one defense against all pathogens. I am betting that low D and RSV development go hand in hand. NIH commission the study. You did commission the Women's Health Initiative for $30 million that was fraudulent and was a Lilly initiative to promote their bone density chemo drug. How about one for improving the health of the nation.
Will there ever be a structured transparent assessment of the ability of ozone water to prevent infectious diseases?
COVID-19 is widely suspected to have originated from a laboratory. Lyme disease is also believed by some researchers to have connections to laboratory research. Whether intentional or accidental, the public keeps seeing the same pattern: pathogens are studied, modified, and sometimes made more dangerous in laboratories, yet very little attention is given to studying how infections might be prevented in the first place.
Agencies such as the CDC, NIH, and FDA spend enormous resources studying pathogens and developing pharmaceutical responses—vaccines, antivirals, and treatments. What receives far less attention is large-scale prevention.
The cycle appears to work like this:
A pathogen emerges.
A pharmaceutical solution is developed.
Billions of dollars follow.
Meanwhile, simple preventative strategies receive little attention.
One example is ozone water.
Ozone dissolved in water has long been recognized as a safe and powerful disinfectant. Both the FDA and EPA acknowledge its effectiveness for food sanitation, a commercial kitchens and water treatment. It can be used to disinfect produce, meat, utensils, food-preparation surfaces, floors, and drains. Its oxidative properties rapidly destroy bacteria, viruses, mold, and other microorganisms, leaving behind only oxygen.
Yet once ozone water leaves the kitchen, discussion about its potential largely disappears.
It is rarely studied as a preventative health tool. It is rarely discussed in public-health strategy. In many cases it is dismissed outright.
This raises an obvious question: if pathogens are the root cause of infectious disease, why are simple methods of reducing or eliminating pathogens in daily environments not studied more seriously?
Many infectious diseases require several days of incubation before symptoms appear. In theory, reducing pathogen exposure during that window could prevent infection from ever taking hold. Advocates argue that ozone water could potentially play a role in sanitation and environmental disinfection because of its ability to rapidly oxidize microorganisms.
If prevention were prioritized—through sanitation technologies, environmental controls, and other non-pharmaceutical approaches—many illnesses might be avoided before they begin. Illness would be prevented rather than treated after it takes hold.
Yet the overwhelming focus of modern medicine remains on treatment after infection occurs.
When prevention is ignored, the remaining options become pharmaceuticals, vaccines, and medical interventions.
And that is where the money is.
A system built around treating illness will naturally invest more heavily in treatments than in prevention. But from a public-health perspective, the most important question remains:
Why are the simplest prevention strategies studied the least?
Will ozone water ever be seriously studied as a preventative tool against infectious disease? If financial incentives continue to favor treatment over prevention, the answer may remain uncertain.
I find it hard to understand why ozone water is not widely promoted. The body reacts very positively to ozone water. Diseases go away never to return, the skin heals rapidly without infection and your brain and body functions better. My personal experience is that I have not been ill in 10 years, not even a sore throat. I wake up every day feeling great. My body is doing better than 25 years ago. I’m playing the best golf of my life, walking the course. Most of my golf buddies have quit because of age related issues. My skin will occasionally bruise but not like it did 10 years ago, and the bruising goes away. Bruises used to pile on top of each other.
My wife has experienced the same results. We are both well into our 70’s and showing no signs of slowing down. I wish I had discovered ozone water sooner.
I’m 66 & more fit than 30 years ago too. Great attitudes, good, happy marriages, excellent diets & supplements, active & lots of humor, all play other important roles. Thanks again!
Ok way over my pay grade regarding medical scientific studies…but not over my pay grade in business and life…I do not have high confidence in some AI endeavors as it sometimes relies so much on published data…let that sink in…so…if there is a secret hidden can it find it? Perhaps some AI is very helpful but IMO it is not generally the definitive solution.
I appreciate this article though as insightful. Certainly can be useful and like all tools might be watered down over time to yield the answer desired. Like all tools will be manipulated…but that’s not a reason to not use it…just know the limitations. And know it will be manipulated IMO.
I will classify that as good news. And so the VA has been bothering me for a while to take the vaccine, I read through quickly what you wrote here and I’m looking for more clarification about what you feel the current vaccine safety profile is?
I personally believe, the current RSV vaccine would fail a competent Risk/Benefit analysis of general use. I to, would love to see an AI assisted … framework … analysis.
I've latched onto that new definition for the left side of the coin. Demoncrates, as in they keep acting like Demons and we should crate them away from the US of A!!
All I can say is i am SO GLAD you, Dr. Malone, have the stamina, the brain and the go to for all this. I would be more than pleased if there are some other ROBUST (in the way of integrity) scientific persons working on all this AI research hand in hand with or in tandem with you.
I have two questions; The statement that the concluding's indicate natural evolution from animal to human spillover; I don't know if this is a good or bad thing. And this sounds like an endorsement for AI assisted assessment and the reasons why: is this true and necessary for future analysis and perhaps the work of ACIP? Maybe I need to read this again.
This is not about the ACIP. This has to do with supporting the State Dept in the area of bioweapons convention treaty compliance monitoring and potential future treaty development of a GOF ban. POTUS wants to see how AI could be used to support this. So this is preliminary data concerning the usefullness of a multi layered approach I have pioneered
"Its authors argue this matters as much as any positive detection would, because a verification tool that cannot confidently clear a known-natural pathogen is of limited value for international confidence-building."
Thank you for this simplified study of RSV using the process you have developed, Dr Malone. I see how important it could be in the verification process of the Biological Weapons Convention. I pray that it can be implemented.
My belief how SARS became COVID though, is kind of hybrid. Under 5G radiation the SARS proteins panicked in the stress of adrenachrome dining in Wuhan. An accidental Gain of Function environment where the SARS was taught to adjust the surfactant in the alveoli and subsequently flood the lungs with plasma, so to become pneumonic.
So the bat/human jump never happened naturally. There is a band right around 5G where the information was streaming. Panicked protein listens very carefully under such conditions.
Thank you for sharing this example of the utility of the analytical system you support.
Certainly an AI system that provides a comprehensive analytical review, applying a six-layer investigative framework, documenting credible evidence of whether a disease process originated in or escaped from a laboratory is of considerable merit.
I think I'm confused as to whether it is able to offer additional utility. For example can elements of its processes indentify threats? Can its analytical process contribute to identification of potential response to a pathogen of concern?
I do appreciate its merits for identifying a breech and likely origins. Can it be used to additional benefits?
Reading about your role, as relates to the system and the objectives its designed to contribute to, I think you well document the utility and merits of your system for such purposes.
I'm shocked. SHOCKED, I TELL YOU!!!
Gambling at Rick’s Cafe level shocked?
Thanks Drs. Malone. Outstanding report and conclusions and proof-of AI Value.
Personal to me because my infant son spent days in Stanford Hospital with Dx: Bronchiolitis. I’ve always assumed RSV and that it was Endemic.
Some parent guilt because his mother and I both worked on the Cell Biology corridor separated only by a single door from the Small Animal Research module. Comtainment standard of the day was cotton lab coats, automatic door, and No Odor Control.
Animal Research was limited to inflamation and assay of antiinflamatory drug candidates but there was an annual All Hands/Labs assay “month” in our wing to process beef organs for steriod residual from our (Syntex’s) large scale field trials. ( Family dogs feasted on beef liver and kidney).
We did good science but, … different times.
The above personal experience took place in 1980.
Sounds like SRI
SRI was very close but it was Syntex USA Inc. founded by Carl Djerassi with others including Dr Abe White, my personal mentor. Syntex was originally founded in Mexico to complete the synthesis of Progesterone from a precursor extracted from the mexican yam. It became the bulk active ingredient in the first birth control pill. That story is told in Djerassi’s book “The Pill, Pygmy Chimps and Degas’ Horse”.
Dr White is described in the book as “Flash”, an emmigrant post doc found working in a Harvard lab attempting steroid total synthesis. He was also main author of “Principles of Biochemistry” (White, Handler and Smith). You might have used it in Med School?
I brought large scale chromatography to Dr White’s Department of Cell Biology to purify enough of a peptide, found in pooled human plasma, for characterization and trial as a Thymocyte “stimulant” that we called “Thymosyn”.
Successful syntex products included Synalar and Aleve.🤓
So...let's go one step further on RSV. Patients with RSV should be tested for blood value of Vitamin D which is a major component of a whole and vibrant immune system which is the number one defense against all pathogens. I am betting that low D and RSV development go hand in hand. NIH commission the study. You did commission the Women's Health Initiative for $30 million that was fraudulent and was a Lilly initiative to promote their bone density chemo drug. How about one for improving the health of the nation.
Will there ever be a structured transparent assessment of the ability of ozone water to prevent infectious diseases?
COVID-19 is widely suspected to have originated from a laboratory. Lyme disease is also believed by some researchers to have connections to laboratory research. Whether intentional or accidental, the public keeps seeing the same pattern: pathogens are studied, modified, and sometimes made more dangerous in laboratories, yet very little attention is given to studying how infections might be prevented in the first place.
Agencies such as the CDC, NIH, and FDA spend enormous resources studying pathogens and developing pharmaceutical responses—vaccines, antivirals, and treatments. What receives far less attention is large-scale prevention.
The cycle appears to work like this:
A pathogen emerges.
A pharmaceutical solution is developed.
Billions of dollars follow.
Meanwhile, simple preventative strategies receive little attention.
One example is ozone water.
Ozone dissolved in water has long been recognized as a safe and powerful disinfectant. Both the FDA and EPA acknowledge its effectiveness for food sanitation, a commercial kitchens and water treatment. It can be used to disinfect produce, meat, utensils, food-preparation surfaces, floors, and drains. Its oxidative properties rapidly destroy bacteria, viruses, mold, and other microorganisms, leaving behind only oxygen.
Yet once ozone water leaves the kitchen, discussion about its potential largely disappears.
It is rarely studied as a preventative health tool. It is rarely discussed in public-health strategy. In many cases it is dismissed outright.
This raises an obvious question: if pathogens are the root cause of infectious disease, why are simple methods of reducing or eliminating pathogens in daily environments not studied more seriously?
Many infectious diseases require several days of incubation before symptoms appear. In theory, reducing pathogen exposure during that window could prevent infection from ever taking hold. Advocates argue that ozone water could potentially play a role in sanitation and environmental disinfection because of its ability to rapidly oxidize microorganisms.
If prevention were prioritized—through sanitation technologies, environmental controls, and other non-pharmaceutical approaches—many illnesses might be avoided before they begin. Illness would be prevented rather than treated after it takes hold.
Yet the overwhelming focus of modern medicine remains on treatment after infection occurs.
When prevention is ignored, the remaining options become pharmaceuticals, vaccines, and medical interventions.
And that is where the money is.
A system built around treating illness will naturally invest more heavily in treatments than in prevention. But from a public-health perspective, the most important question remains:
Why are the simplest prevention strategies studied the least?
Will ozone water ever be seriously studied as a preventative tool against infectious disease? If financial incentives continue to favor treatment over prevention, the answer may remain uncertain.
I like the way you think, Mike!
Guess it’s up to the forces of real individuals, disseminating & advocating. Thank you!!
I find it hard to understand why ozone water is not widely promoted. The body reacts very positively to ozone water. Diseases go away never to return, the skin heals rapidly without infection and your brain and body functions better. My personal experience is that I have not been ill in 10 years, not even a sore throat. I wake up every day feeling great. My body is doing better than 25 years ago. I’m playing the best golf of my life, walking the course. Most of my golf buddies have quit because of age related issues. My skin will occasionally bruise but not like it did 10 years ago, and the bruising goes away. Bruises used to pile on top of each other.
My wife has experienced the same results. We are both well into our 70’s and showing no signs of slowing down. I wish I had discovered ozone water sooner.
I’m 66 & more fit than 30 years ago too. Great attitudes, good, happy marriages, excellent diets & supplements, active & lots of humor, all play other important roles. Thanks again!
Ok way over my pay grade regarding medical scientific studies…but not over my pay grade in business and life…I do not have high confidence in some AI endeavors as it sometimes relies so much on published data…let that sink in…so…if there is a secret hidden can it find it? Perhaps some AI is very helpful but IMO it is not generally the definitive solution.
I appreciate this article though as insightful. Certainly can be useful and like all tools might be watered down over time to yield the answer desired. Like all tools will be manipulated…but that’s not a reason to not use it…just know the limitations. And know it will be manipulated IMO.
I will classify that as good news. And so the VA has been bothering me for a while to take the vaccine, I read through quickly what you wrote here and I’m looking for more clarification about what you feel the current vaccine safety profile is?
I personally believe, the current RSV vaccine would fail a competent Risk/Benefit analysis of general use. I to, would love to see an AI assisted … framework … analysis.
Off the grid here on topics, but just read that Jasmine Crockett lost big time in the Texas Demoncrate primaries.
I've latched onto that new definition for the left side of the coin. Demoncrates, as in they keep acting like Demons and we should crate them away from the US of A!!
Comforting to know RSV was not man made. Viruses are already too efficient at transforming without our help.
All I can say is i am SO GLAD you, Dr. Malone, have the stamina, the brain and the go to for all this. I would be more than pleased if there are some other ROBUST (in the way of integrity) scientific persons working on all this AI research hand in hand with or in tandem with you.
I have two questions; The statement that the concluding's indicate natural evolution from animal to human spillover; I don't know if this is a good or bad thing. And this sounds like an endorsement for AI assisted assessment and the reasons why: is this true and necessary for future analysis and perhaps the work of ACIP? Maybe I need to read this again.
This is not about the ACIP. This has to do with supporting the State Dept in the area of bioweapons convention treaty compliance monitoring and potential future treaty development of a GOF ban. POTUS wants to see how AI could be used to support this. So this is preliminary data concerning the usefullness of a multi layered approach I have pioneered
Got it, thank you and "good job!" You are way ahead of the field in this use, if you ask me.
"Its authors argue this matters as much as any positive detection would, because a verification tool that cannot confidently clear a known-natural pathogen is of limited value for international confidence-building."
This almost looks like confirmation bias.
Thank you for this simplified study of RSV using the process you have developed, Dr Malone. I see how important it could be in the verification process of the Biological Weapons Convention. I pray that it can be implemented.
That was my belief all along.
https://drive.google.com/file/d/1h3DKTftFp5hcX5ze0hSIBGoIg4011yTU
My belief how SARS became COVID though, is kind of hybrid. Under 5G radiation the SARS proteins panicked in the stress of adrenachrome dining in Wuhan. An accidental Gain of Function environment where the SARS was taught to adjust the surfactant in the alveoli and subsequently flood the lungs with plasma, so to become pneumonic.
https://drive.google.com/file/d/1BHk__WZ0GOg0GRkUGHvTXns7R_6rG72o
So the bat/human jump never happened naturally. There is a band right around 5G where the information was streaming. Panicked protein listens very carefully under such conditions.
Thank you for sharing this example of the utility of the analytical system you support.
Certainly an AI system that provides a comprehensive analytical review, applying a six-layer investigative framework, documenting credible evidence of whether a disease process originated in or escaped from a laboratory is of considerable merit.
I think I'm confused as to whether it is able to offer additional utility. For example can elements of its processes indentify threats? Can its analytical process contribute to identification of potential response to a pathogen of concern?
I do appreciate its merits for identifying a breech and likely origins. Can it be used to additional benefits?
Reading about your role, as relates to the system and the objectives its designed to contribute to, I think you well document the utility and merits of your system for such purposes.
Lactobacillus johnsonii has demonstrated significant protective effects against respiratory syncytial virus “
https://www.perplexity.ai/search/lactobacillus-johnsonii-agains-JbpLbC0ETNCoqbL.WfbVmg