Well Being: Biohacking with Urolithin A
A great anti-aging supplement: expensive but worth it
I recently stumbled across a supplement for which clinical data were released on October 31, 2025. The data shook my biohacking worldview regarding anti-aging.
The article in Nature Aging, titled “Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial,” reveals that taking Urolithin A daily for a month can have exciting effects on middle-aged healthy adults. It helps shift the immune system to a more youthful state, with more naive CD8+ T cells (Helper T), a less exhausted phenotype, better metabolic flexibility, stronger activation responses, and improved phagocytosis. You are probably unaware of the problem of “immunosenescence,” but aging of the immune system (particularly cellular immune responses) is a major contributor to morbidity and mortality in the elderly. These positive changes associated with Urolithin A suggest that supporting mitochondrial health, by encouraging mitophagy and mitochondrial renewal, might be a helpful way to combat some aspects of immune aging.
Furthermore, other clinical trials have documented that this supplement improves muscle strength and endurance, particularly in older adults.
What is Urolithin A and Dosing:
The rest of this article has been paywalled.Also, as a service to our paid subscribers, we have now tagged all of our well-being articles, which are listed on a single webpage for you to peruse at your leisure, and we have done the same for our homesteading articles. There are at least a hundred articles all told, so enjoy!
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