Fat cells do indeed remember. I was working my way through a broccoli side dish when one cell spoke up reminiscently. "Remember those great chili dogs, fried onion rings, and orange frosty we had at The Varsity in 2017?" I said forget about it, those days are over.
Doubt diet alone accounts for the increase in cancer particularly in kids. The immune system has an important surveillance role in detecting and destroying newly developed cancer cells. Screwing with developing immune systems with 80 or so vaccines, most unneeded, cannot be a boon for development in immune surveillance.
Such sound advice. Sugar is really the enemy, along with additives and seed oils. And they are easier to eliminate than you think. Cut out all soda, read labels, and cook with fresh ingredients. Eggs are not the enemy. Neither is meat. Fresh vegetables or if necessary frozen. And exercise, even if just walking. Doc Malone is such a treasure. Why he isn't running our government health services is a mystery (or not given the fortunes at risk if we get healthier). And I'd also put him in charge of a task force to take health care away from the predatory insurance companies. Wonder your take on Callie Means, Doc. He was a bit naive but his criticisms ring mostly true.
This is an excellent substack article by Sayer Ji as to what GLP-1 injections for weight loss can also do to your body, none of which is good. Along with losing weight, you also lose muscle, specifically skeletal muscle. When you stop taking the GLP-1 injections, the fat/weight typically returns, but the muscle does not. There are also a host of other very concerning potential negative effects from using these injectables that the average person may not know..https://sayerji.substack.com/p/silencing-the-alarm-why-glp-1-drugs?utm_campaign=post&utm_medium=email
In the 12 Step Program, a 4th Step Promise is “When we straighten out the Spiritual Malady, we recover physically and mentally [and emotionally]”. The meetings are the support group, NOT THE TREATMENT.
The treatment is The Steps which results in a transformational experience via facing and integrating unprocessed emotion occluded by all manner of substances and behaviors. The medicine for the wound is in the wound.
A 10th Step promise comes true “We haven’t even sworn off [promised ourselves we can do it with willpower] [the desired effect] just comes”. From the vantage point of humble surrender, we live in the Truth of “God doing for us what we couldn’t do for ourselves”. 10-18-85.
First, my recollection is that Dr. Malone covered the topic of fat cell memory months before the Nature study referenced herein (on or about 6-24-24). Secondly, I'll trust Dr. Malones' analysis long before that of Nature, closely affiliated with the Nature Medicine that produced the Proximal Origin paper.
Great article, but it does not provide meaningful advice for recovering from childhood obesity. My 13 Y/O great-grandson, whom I have raised since infancy, now weighs 225 pounds and is approximately 5'7" tall. I have made a concentrated effort all of his life to maintain a healthy diet - minimal sugar intake, almost no processed foods, eliminating seed oils from his diet, eliminating unhealthy snacks, balanced meals, etc. but it has had minimal effect. He does not normally eat unhealthy food, but he eats large quantities. He can be full to the point of stomach pain, and will be hungry and searching for food 10 minutes later. Putting him on a diet is virtually impossible, and his pediatrician just keeps saying, " Limit his snacking, see a dietitian", etc. I have consulted dietitians in the past and have found them to be totally useless, generally just handing me a pamphlet and a list of food groups. Wow. He's now paying the price in school with bullying and teasing from other kids, making Middle School that much more difficult. And don't get me started on school lunches, even at the private school he attends.
They keep renaming fatty liver disease so most of the patients can’t tell this month’s new health care provider the name of their problem. 🙄
The availability of lots of “free” food is a signal to go elsewhere. Healthcare professionals get fat on free food.
How about those generations of exogenous hormones given to women for generations? Do you think any of them had epigenetic and metabolic effects affecting progeny??
Progestin containing shots and implants were the most obvious patient inflaters, but many other hormone analogs seemed to ‘work’ too.
Pharma has long seemed to load up people who are not sick, before they understand what they’re doing.
I won’t recommend the GLP1 drugs, nor the unapproved ones that are all over the grey and black markets.
The best obesity preventing advice I got long ago was to avoid gaining more weight. That, as well as eating yummy weeds, has saved me a lot of trouble so far. I’ve had some food abusing fun while retaining my mobility, by having a sort of red line on the scale
I believe that too much sugar causes inflammatory pain. Seems that the funky ingredients in precessed desserts are worse than plain old sucrose or honey. So make your own dessert when you ‘gotta have it’.
This article, like many, keeps using the vague terms like the cell remembers, the cells get used to, or the cells change somehow. Let us be more specific, that is, cells continually undergo epigenetic changes in response to the cell's environment. This likely occurs in all the cells in your body.
By epigenetic changes, I mean the expression of your DNA. You say the fat cells remember, but really what you mean in that in response to the environment, the cell as changed the expression of its DNA. The cells did not undergo some type of mutation, as the DNA is the same as it is in all the other cells of your body, it just change the expression.
These epigenetic changes can be temporary, long lasting, or even permanent. Consider your blastocyst in embryonic development. At the start they can develop into any cell. That is, you could remove one of these blastocyst cells for analysis and no harm will be done. But at some point, they become committed to a certain type of cell, which is a permanent change. The DNA did not change, only the expression.
This also most easily demonstrated in the development of obesity. After years of exposure to repeated and rapid elevations of glucose levels, you slowly develop insulin resistance. Your insulin is perfectly fine, but now it requires more insulin to get the same result. Elevated insulin is the driver to fat cells to get larger. Eventually elevated insulin produces man other cells to malfunction.
If you only have prediabetes, you may be able to to reverse some of these epigenetic changes. If you progress to type 2 diabetes, you may not. This is one of the main benefits of GLP-1, that is, it prevents the progression to T2DM. Once this occurs, you may be able to get your glucose level to normal with proper diet and perhaps medications, but you still have T2DM and without vigilance will get elevated insulin again.
Kelly Gregg MD Epigenetics and Pregnancy; Fat Newborns and Infants.
I was just reading yesterday a section in "Biological Elegance" zachbushmd.com about the" GLP-1 receptor is literally derived from lizard poison. Nature devised the compound to end life." His take on our desire to basically kill the appetite, also includes the notion of being hungry for the emotional fullness of life that is missing for so many. Another avenue for the pharma solution. As he says, we will surely look fit at our funeral. (A Midwestern Doctor has a post on this same issue. midwesterndoctor.com)
I don't read articles about fat anymore - in some cases, it is good to be overweight. For certain women over the fertility age, or who had surgery like me, the fat cells replace to a certain amount the hormones, so told me my OBgyn. Also, two friends who were very sick and were overweight, and could not eat for weeks, lost the fat and did not regain it. Another friend who was already skinny, was paralyzed for several weeks, and never regained strength, and died last year at 74. That extra fat also helps with the cold. No, fat is not a conversation piece anymore.
There's fat and there's obese. Maybe some moderate weight is reasonable but not 100 libs. We won't have sixpacks in our sixties or seventies but carrying excess weight is a burden. Just try carrying around a 10 lb weight plate all day. Or how about a 25 lb. weight??? You'd be exhausted.
Seems like you are a man. I am talking about women. We are built differently. And even men might want a bit extra. Also, this fat is not a bag you carry. It is in your body. Do you feel uncomfortable wearing 5 extra pounds of clothes in cold weather?
Now that comment about vaccines being a potential culprit in health problems. So true. Another bad development for young bodies. That needs to end or be vastly reduced.
Such a lengthy essay, and full of good information such as statistics on weight in our population. My thinking has been having kids sitting is schools for years has bad consequences. The body evolved to move and run and this is not happening enough now. Adult jobs also involve a lot of sitting. Maybe companies could insist on exercise at work. Then of course computers and phones. You hear of many young types being involved with computer interactions and computer games for hours. I agree with all your advice on eating, sleeping, exercise which I do and am not overweight. But with all the sitting that is done in school at work in cars, evidently there are many who just are unable to help the body do what it needs to do. I think if we could adjust schools to have more sports and exercise there might be hope, then maybe at a young age Americans could get moving.
Great review. I wish the rest of the Medical Industrial Complex would start paying attention. Oh wait it is not in their best financial interest to help Americans actually get healthy.
Repost:
Fat cells do indeed remember. I was working my way through a broccoli side dish when one cell spoke up reminiscently. "Remember those great chili dogs, fried onion rings, and orange frosty we had at The Varsity in 2017?" I said forget about it, those days are over.
My fat cells told me this morning that memory is the second thing to go.
Ah, the Varsity! Fun memories! I don’t live in Atlanta anymore, but if I did, I can’t imagine I would go very often these days!
Doubt diet alone accounts for the increase in cancer particularly in kids. The immune system has an important surveillance role in detecting and destroying newly developed cancer cells. Screwing with developing immune systems with 80 or so vaccines, most unneeded, cannot be a boon for development in immune surveillance.
Immune dysfunction can now be tied to hyperinsulinemia which has direct immune modulation at the cellular level.
💯
Such sound advice. Sugar is really the enemy, along with additives and seed oils. And they are easier to eliminate than you think. Cut out all soda, read labels, and cook with fresh ingredients. Eggs are not the enemy. Neither is meat. Fresh vegetables or if necessary frozen. And exercise, even if just walking. Doc Malone is such a treasure. Why he isn't running our government health services is a mystery (or not given the fortunes at risk if we get healthier). And I'd also put him in charge of a task force to take health care away from the predatory insurance companies. Wonder your take on Callie Means, Doc. He was a bit naive but his criticisms ring mostly true.
This is an excellent substack article by Sayer Ji as to what GLP-1 injections for weight loss can also do to your body, none of which is good. Along with losing weight, you also lose muscle, specifically skeletal muscle. When you stop taking the GLP-1 injections, the fat/weight typically returns, but the muscle does not. There are also a host of other very concerning potential negative effects from using these injectables that the average person may not know..https://sayerji.substack.com/p/silencing-the-alarm-why-glp-1-drugs?utm_campaign=post&utm_medium=email
Great Summary, Docs.
RE:Support Group
In the 12 Step Program, a 4th Step Promise is “When we straighten out the Spiritual Malady, we recover physically and mentally [and emotionally]”. The meetings are the support group, NOT THE TREATMENT.
The treatment is The Steps which results in a transformational experience via facing and integrating unprocessed emotion occluded by all manner of substances and behaviors. The medicine for the wound is in the wound.
A 10th Step promise comes true “We haven’t even sworn off [promised ourselves we can do it with willpower] [the desired effect] just comes”. From the vantage point of humble surrender, we live in the Truth of “God doing for us what we couldn’t do for ourselves”. 10-18-85.
I note a couple of things.
First, my recollection is that Dr. Malone covered the topic of fat cell memory months before the Nature study referenced herein (on or about 6-24-24). Secondly, I'll trust Dr. Malones' analysis long before that of Nature, closely affiliated with the Nature Medicine that produced the Proximal Origin paper.
Great article, but it does not provide meaningful advice for recovering from childhood obesity. My 13 Y/O great-grandson, whom I have raised since infancy, now weighs 225 pounds and is approximately 5'7" tall. I have made a concentrated effort all of his life to maintain a healthy diet - minimal sugar intake, almost no processed foods, eliminating seed oils from his diet, eliminating unhealthy snacks, balanced meals, etc. but it has had minimal effect. He does not normally eat unhealthy food, but he eats large quantities. He can be full to the point of stomach pain, and will be hungry and searching for food 10 minutes later. Putting him on a diet is virtually impossible, and his pediatrician just keeps saying, " Limit his snacking, see a dietitian", etc. I have consulted dietitians in the past and have found them to be totally useless, generally just handing me a pamphlet and a list of food groups. Wow. He's now paying the price in school with bullying and teasing from other kids, making Middle School that much more difficult. And don't get me started on school lunches, even at the private school he attends.
They keep renaming fatty liver disease so most of the patients can’t tell this month’s new health care provider the name of their problem. 🙄
The availability of lots of “free” food is a signal to go elsewhere. Healthcare professionals get fat on free food.
How about those generations of exogenous hormones given to women for generations? Do you think any of them had epigenetic and metabolic effects affecting progeny??
Progestin containing shots and implants were the most obvious patient inflaters, but many other hormone analogs seemed to ‘work’ too.
Pharma has long seemed to load up people who are not sick, before they understand what they’re doing.
I won’t recommend the GLP1 drugs, nor the unapproved ones that are all over the grey and black markets.
The best obesity preventing advice I got long ago was to avoid gaining more weight. That, as well as eating yummy weeds, has saved me a lot of trouble so far. I’ve had some food abusing fun while retaining my mobility, by having a sort of red line on the scale
I believe that too much sugar causes inflammatory pain. Seems that the funky ingredients in precessed desserts are worse than plain old sucrose or honey. So make your own dessert when you ‘gotta have it’.
I don't suppose for a moment that multiple vaccines - levels never mind the mMRNA types - have anything whatsoever to do with elevated insulin levels?
This article, like many, keeps using the vague terms like the cell remembers, the cells get used to, or the cells change somehow. Let us be more specific, that is, cells continually undergo epigenetic changes in response to the cell's environment. This likely occurs in all the cells in your body.
By epigenetic changes, I mean the expression of your DNA. You say the fat cells remember, but really what you mean in that in response to the environment, the cell as changed the expression of its DNA. The cells did not undergo some type of mutation, as the DNA is the same as it is in all the other cells of your body, it just change the expression.
These epigenetic changes can be temporary, long lasting, or even permanent. Consider your blastocyst in embryonic development. At the start they can develop into any cell. That is, you could remove one of these blastocyst cells for analysis and no harm will be done. But at some point, they become committed to a certain type of cell, which is a permanent change. The DNA did not change, only the expression.
This also most easily demonstrated in the development of obesity. After years of exposure to repeated and rapid elevations of glucose levels, you slowly develop insulin resistance. Your insulin is perfectly fine, but now it requires more insulin to get the same result. Elevated insulin is the driver to fat cells to get larger. Eventually elevated insulin produces man other cells to malfunction.
If you only have prediabetes, you may be able to to reverse some of these epigenetic changes. If you progress to type 2 diabetes, you may not. This is one of the main benefits of GLP-1, that is, it prevents the progression to T2DM. Once this occurs, you may be able to get your glucose level to normal with proper diet and perhaps medications, but you still have T2DM and without vigilance will get elevated insulin again.
Kelly Gregg MD Epigenetics and Pregnancy; Fat Newborns and Infants.
I was just reading yesterday a section in "Biological Elegance" zachbushmd.com about the" GLP-1 receptor is literally derived from lizard poison. Nature devised the compound to end life." His take on our desire to basically kill the appetite, also includes the notion of being hungry for the emotional fullness of life that is missing for so many. Another avenue for the pharma solution. As he says, we will surely look fit at our funeral. (A Midwestern Doctor has a post on this same issue. midwesterndoctor.com)
I don't read articles about fat anymore - in some cases, it is good to be overweight. For certain women over the fertility age, or who had surgery like me, the fat cells replace to a certain amount the hormones, so told me my OBgyn. Also, two friends who were very sick and were overweight, and could not eat for weeks, lost the fat and did not regain it. Another friend who was already skinny, was paralyzed for several weeks, and never regained strength, and died last year at 74. That extra fat also helps with the cold. No, fat is not a conversation piece anymore.
There's fat and there's obese. Maybe some moderate weight is reasonable but not 100 libs. We won't have sixpacks in our sixties or seventies but carrying excess weight is a burden. Just try carrying around a 10 lb weight plate all day. Or how about a 25 lb. weight??? You'd be exhausted.
Seems like you are a man. I am talking about women. We are built differently. And even men might want a bit extra. Also, this fat is not a bag you carry. It is in your body. Do you feel uncomfortable wearing 5 extra pounds of clothes in cold weather?
You are correct about the gender differences of fat but you minimize the dangers of obesity.
Now that comment about vaccines being a potential culprit in health problems. So true. Another bad development for young bodies. That needs to end or be vastly reduced.
Such a lengthy essay, and full of good information such as statistics on weight in our population. My thinking has been having kids sitting is schools for years has bad consequences. The body evolved to move and run and this is not happening enough now. Adult jobs also involve a lot of sitting. Maybe companies could insist on exercise at work. Then of course computers and phones. You hear of many young types being involved with computer interactions and computer games for hours. I agree with all your advice on eating, sleeping, exercise which I do and am not overweight. But with all the sitting that is done in school at work in cars, evidently there are many who just are unable to help the body do what it needs to do. I think if we could adjust schools to have more sports and exercise there might be hope, then maybe at a young age Americans could get moving.
Great review. I wish the rest of the Medical Industrial Complex would start paying attention. Oh wait it is not in their best financial interest to help Americans actually get healthy.